The leaves and flowers have long been used as a cough remedy. They relieve dry coughs, wheezing, asthma, bronchitis, emphysema, whooping cough, difficulty in breathing, or any congestion in the respiratory system. Coltsfoot is very mucilaginous and is soothing to the mucous membranes. It has anti-inflammatory properties which is useful in sore throats, laryngitis, flu and colds.

The leaves demonstrate high levels of zinc, which would explain some of the plant's anti-inflammatory and immune-boosting properties. The leaves can also be smoked to help clear the lung passages and relieve chest discomforts.

Coltsfoot is a mild diuretic and can be used in bladder inflammations. The fresh leaves can be put in abscesses, boils and ulcers with great service.